Literature summary extracted from

Francis, S.E.; Gluzman, I.Y.; Oksman, A.; Knickerbocker, A.; Mueller, R.; Bryant, M.L.; Sherman, D.R.; Russell, D.G.; Goldberg, D.E.
Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase (1994), EMBO J., 13, 306-317.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.23.38	-	Plasmodium falciparum

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.23.38	additional information	inhibition of the enzyme blocks the essential pathway of hemoglobin degradation, leading to death of the organism	Plasmodium falciparum

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.23.38	vacuole	digestive vacuole	Plasmodium falciparum	5773	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.23.38	Hemoglobin + H2O	Plasmodium falciparum	the enzyme initiates the hemoglobin degradation pathway in Plasmodium	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.23.38	Plasmodium falciparum	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.23.38	Hemoglobin + H2O	the enzyme initiates the hemoglobin degradation pathway in Plasmodium	Plasmodium falciparum	?	-	?
3.4.23.38	hemoglobin alpha-chain + H2O	-	Plasmodium falciparum	?	-	?

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Release 2023.1 (January 2023)